Imaging of pheochromocytoma and paraganglioma: moving beyond “lumpology” with SSTR, FDG and MIBG molecular imaging
نویسندگان
چکیده
منابع مشابه
Imaging of pheochromocytoma and paraganglioma: moving beyond “lumpology” with SSTR, FDG and MIBG molecular imaging
Learning objectives Cancer staging traditionally uses CT or MRI for detecting suspected malignant lesions with characterisation performed by histopathology following biopsy. In this “lumpology” paradigm, the number, size and location of lesions are used to determine prognosis and guide treatment strategies. To provide an educational exhibit to highlight the utility of molecular imaging to diagn...
متن کاملMoving Beyond "Lumpology": PET/CT Imaging of Pheochromocytoma and Paraganglioma.
High somatostatin receptor expression on the cell membrane of succinate dehydrogenase mutation-related pheochromocytoma and paraganglioma provides a potential target for imaging and therapy. (68)Ga-DOTATATE positron emission PET/CT may represent a new gold standard for staging pheochromocytoma/paraganglioma and have future therapeutic implications.
متن کاملPheochromocytoma and paraganglioma: imaging characteristics
The accurate diagnosis of adult pheochromocytoma and paraganglioma necessitates a multidisciplinary approach that includes clinical history, biochemical testing, and multimodality imaging such as computed tomography, magnetic resonance imaging, and nuclear medicine studies. This review illustrates the different imaging characteristics of primary adult pheochromocytomas as well as both sympathet...
متن کاملPheochromocytoma and Paraganglioma: Current Functional and Future Molecular Imaging
Paragangliomas are neural crest-derived tumors, arising either from chromaffin sympathetic tissue (in adrenal, abdominal, intra-pelvic, or thoracic paraganglia) or from parasympathetic tissue (in head and neck paraganglia). They have a specific cellular metabolism, with the ability to synthesize, store, and secrete catecholamines (although most head and neck paragangliomas do not secrete any ca...
متن کاملUtility of 123I-MIBG Standardized Uptake Value in Patients with Refractory Pheochromocytoma and Paraganglioma
Objective(s): Single-photon emission computed tomography (SPECT) using metaiodobenzylguanidine (MIBG) is an important diagnostic tool for the treatment of refractory pheochromocytoma and paraganglioma (PPGL). Owing to the difficulty of SPECT quantification, the tumour-to-background ratio (TBR) is used to assess disease activity. However, the utility of TBR is limited o...
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ژورنال
عنوان ژورنال: Cancer Imaging
سال: 2015
ISSN: 1470-7330
DOI: 10.1186/1470-7330-15-s1-p49